Question: What Is Pharmacokinetic Tolerance?

What does it mean if you have a low tolerance?

Individuals with low frustration tolerance may give up on tough tasks immediately.

The mere thought of having to wait in line or work on a task that they don’t understand may feel intolerable.

If you fall on the low end of the frustration tolerance spectrum, it may cause some problems in your life..

What is another word for tolerance?

SYNONYMS FOR tolerance 1, 2 patience, sufferance, forbearance; liberality, impartiality, open-mindedness.

What does pessimistic mean?

pertaining to or characterized by pessimism or the tendency to expect only bad outcomes; gloomy; joyless; unhopeful: His pessimistic outlook kept him from applying for jobs for which he was perfectly qualified.

Why does ephedrine cause Tachyphylaxis?

When given in repeated doses, tachyphylaxis occurs, probably because of depleted norepinephrine stores. Ephedrine causes an increase in systolic, diastolic, and MAPs. It increases myocardial contractility, heart rate, and cardiac output (see Table 25.1).

Why does tolerance occur in pharmacology?

Usually, tolerance develops because metabolism of the drug speeds up (often because the liver enzymes involved in metabolizing drugs become more active) and because the number of sites (cell receptors) that the drug attaches to or the strength of the bond (affinity) between the receptor and drug decreases (see …

What is pharmacodynamic tolerance?

Pharmacodynamic tolerance refers to instances of tolerance that involve either (a) adaptive changes in receptor binding, or (b) recruitment of processes that limit or oppose the effects of the drug on receptor-mediated signaling pathways.

What is the difference between Tachyphylaxis and tolerance?

Tolerance is the requirement of higher doses of a drug to produce a given response. … Tachyphylaxis is defined as a rapid decrease in response to repeated doses over a short time period.

What tolerance means?

1 : capacity to endure pain or hardship : endurance, fortitude, stamina. 2a : sympathy or indulgence for beliefs or practices differing from or conflicting with one’s own. b : the act of allowing something : toleration.

What are the three types of fits?

The three main categories are: Clearance fit. Transition fit. Interference fit.

What is tolerance in steel?

A tolerance is a range of acceptable measurements outside of the nominal dimension. A tolerance or set of tolerances is made to give the manufacturer of a metal product some measurement allowance in the production process.

What does Neuroadaptation mean?

Neuroadaptations are anatomic or physiologic changes that attempt to maintain homeostasis and occur following the use of cocaine, methamphetamine (Meth), and 3,4-methylenedioxymethamphetamine (MDMA).

Why is it important to have tolerance for others?

Tolerance is an important concept that helps people to live together peacefully. To be tolerant means that you accept other people’s opinions and preferences, even when they live in a way that you don’t agree with. … Tolerant people show strength in that they can deal with different opinions and perspectives.

What are the types of tolerance?

Types of Geometric TolerancesForm Tolerance (Form Deviation)Form Tolerance and Location Tolerance (Profile Tolerance of Line / Profile Tolerance of Plane)Orientation Tolerance.Location Tolerance (Location Deviation)Run-out Tolerance (Run-out Deviation)Maximum Material Condition (MMC) and Least Material Condition (LMC)

What is meant by drug tolerance?

Tolerance is a person’s diminished response to a drug, which occurs when the drug is used repeatedly and the body adapts to the continued presence of the drug. Resistance refers to the ability of microorganisms or cancer cells to withstand the effects of a drug usually effective against them.

What are the 2 types of tolerance?

There are two types of drug tolerance: physiological and behavioral. Physical tolerance occurs in at the cellular level. The body increases the rate at which the drug is broken down (metabolized).

What causes tolerance?

Usually, tolerance develops because metabolism of the drug speeds up (often because the liver enzymes involved in metabolizing drugs become more active) and because the number of sites (cell receptors) that the drug attaches to or the strength of the bond (affinity) between the receptor and drug decreases (see …

What is acute tolerance?

Acute tolerance can be defined as a decrease in response to alcohol within a single exposure to the drug, which occurs independently of changes in blood alcohol concentrations (BACs).

How can Tachyphylaxis be prevented?

Tolerance, termed tachyphylaxis, develops quickly to the effects of nitrates. To prevent tolerance from occurring there should be a nitrate-free interval (at least 12 hours) during each 24-hour period (typically overnight).

Is drug tolerance reversible?

Drug tolerance is indicative of drug use but is not necessarily associated with drug dependence or addiction. The process of tolerance development is reversible (e.g., through a drug holiday) and can involve both physiological factors and psychological factors.

Is tolerance a good thing?

When tolerance is placed within the moral domain relating to fairness, justice and respect and avoiding causing harm to others, it can only be viewed as a positive moral virtue. Psychological research supports the idea that tolerance is better placed within the moral domain.

What are the effects of tolerance?

With certain classes of drugs, like opioids, tolerance can increase the risk of dependence, addiction, and overdose. When your body develops tolerance, using higher doses increases the risk of overdose. A benefit of tolerance might be fewer side effects as your body gets used to the medication.